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The Lancet, 395(10234), 14171418

10.1007/978-1-4939-2095-2_10 11 ChungJ.ChenC.PawB

An important caveat of these models, however, is the substantial discrepancy in disease severity and progression between humans and mice for a given mutant protein

While efforts are well-intentioned, many people overestimate their risk or underestimate their supplemental doses, which can cause added symptoms such as headaches, nausea, vomiting, diarrhea, itching and skin rashes