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No specific receptor has been definitively identified

For every 1 gram daily of carnitine supplementation, up to 4 grams, the results showed a significant mean reduction in the following compared with controls: BMI: 0.37 kg/m3 Fasting plasma glucose: 3 mg/dL HbA1c: 0.16% LDL cholesterol: 4 mg/dL Total cholesterol: 5 mg/dL Triglycerides: 6 mg/dL The greatest reductions in BMI were observed at 2 grams daily whereas serum triglycerides, total cholesterol, and fasting plasma glucose had the greatest improvements at 4 grams daily (Mirrafiei 2024)

Development of auto-antibodies Some cobalamin preparations in rare cases can stimulate an allergenic response where there is development of antibodies to the cobalmin injected

Examples two and three also indicate that focusing on point estimates such as the intent to treat and local average treatment effect alone would lead a policymaker to over-estimate the potential impact of the job-training program