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Advantages of oral form over IM injection: Less nursing time on injections Less complexity of care Less discomfort/pain Less bleeding in patients who take anticoagulants Less costly according to some analyses Disadvantages of oral form over IM injection:: Greater risk of non-compliance In 1991, a survey done on Minneapolis internists led one commentary to conclude that oral vitamin B 12 replacement for pernicious anemia was one of medicines best kept secret. 18 In 1996, when the survey was repeated again in the same area, awareness and use of oral vitamin B 12 for pernicious anemia had increased substantially (019%), but the majority of doctors still remain unaware of this treatment option (61%)

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Assuming a continuous bleed system that is 100% effective, thus for this system, the minimum makeup water requirement is: Evaporation + Drift + Blowdown = 0.442kg/s + 0.0239kg/s + 0.0645kg/s = 0.53kg/s As the density of water is approximately 998 kg/m3 at sea level and habitable outdoor temperatures, or ~1 kg/L, this would be 0.53 L/s for make-up water

Am J Clin Nutr (2007) 85:83744