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Independent function of two destruction domains in hypoxia-inducible factor- chains activated by prolyl hydroxylation

Incapsula incident ID: 351000170039486647-82117313706263630

Therefore, in myeloid cells, PEFs primarily modulate MDSCs through the NLRP3/IL-1 signaling pathway and regulate tumor-associated macrophages via the CCLs/CCR2 signaling axis ( Figure 3 )