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GregoryMSHackettCGAbernathyEFLeeKSSaffRRHohlbaumAMet al

4.1 Ferroptosis promoter and inducer Predicated upon the intricate mechanisms of ferroptosis, the operational modalities of ferroptosis inducers can be broadly classified into several categories: The initial category functions by thwarting system Xc-to impede the influx of cystine, accomplished primarily by quelling the activity of SLC7A11, thereby orchestrating a decrement in intracellular GSH levels ( 4.1.1 Inhibiting system Xc - inducing ferroptosis Erastin emerges as a prominent contender among the extensively studied inducers of ferroptosis

The potentially protective actions of the EETs involve the inhibition of apoptosis, the promotion of pro-survival signaling as well as preserved mitochondrial structure and function