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Rather than raising NAD+ systemically (as NMN or NR supplementation does), NNMT inhibition preserves NAD+ specifically in the tissue where metabolic dysfunction is most pronounced a precision approach that appeals to researchers studying tissue-specific metabolic regulation

Raloxifene is a new SERM developed for osteoporosis that appears to prevent breast cancer (Lewis and Jordan, 2005)

This clinician-guided option is designed for men who need additional metabolic support beyond diet and exercise alone

The authors express concern that there is not yet clear guidance on supplementation route and methods, and they discuss studies exploring this