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Proc Natl Acad Sci U S A (1986) 83(20):79324.10.1073/pnas.83.20.7932 221 YakarSLiuJLStannardBButlerAAcciliDSauerBet alNormal growth and development in the absence of hepatic insulin-like growth factor I

Notably, in a clinical trial of patients with severe acute pancreatitis, synbiotic prophylaxis containing Bifidobacterium , Lactobacillus , cornstarch, and maltodextrin was associated with a 2.5-fold increase in mortality and bowel ischemia compared to placebo (122)