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Clinical cohort studies confirm that cerebrospinal fluid levels of lipid peroxidation markers (e.g., MDA, 8-OHdG) are significantly elevated in APOE4 carriers compared to APOE2 carriers, exhibiting a strong positive correlation with the rate of hippocampal atrophy (199)

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An early work, presented in 1995 by Dentico and colleagues, evaluated the effect of 30-day administration of high doses of intravenous or intramuscular GSH on liver cytolysis indexes in patients with chronic steatosic liver disease (77)

Groups of 10 male Wistar rats were exposed to acetaldehyde, for 6 h/day, 5 days/week, for 4 weeks, in three different patterns: (a) as a continuous daily exposure of 6 h to 0, 270, or 900 mg/m 3 (0, 150, or 500 ppm), (b) as two daily exposures of 3 h to similar concentrations with an intervening 1.5-h period with no exposure, or (c) as two daily 3-h periods of exposure to similar concentrations with an intervening 1.5-h period with eight short (5-min) peaks of 6 times the basic concentration, resulting in time-weighted average concentrations of 0, 255, or 1050 mg/m 3 , respectively