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Nevertheless, in vitro studies on blood vessels have shown that GLP-1RAs inhibit vascular smooth muscle cell proliferation, reduce reactive oxygen species, and increase nitric oxide in vascular endothelial cells [37]

The peptide also interacts with the immune system by influencing gene expression and modulating cytokine balance

An in vivo test for genotoxicity, generally a test for chromosomal damage using rodent hematopoietic cells, either for micronuclei or for chromosomal aberrations in metaphase cells

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