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doi: 10.1016/j.bbamcr.2011.03.001

d , Relative cell numbers after 72 h of treatment of HCC-1806 cells without or with MK-571 (15 M) in control (208 M cystine

[30] Beyond xylulose 5-phosphate, sedoheptulose 7-phosphate, and fructose 6-phosphate, transketolase is also capable of using other 2-keto sugars and a variety of aldose phosphates as substrates

Notably, L2HG-induced ferroptosis occurs independently of impaired cystine uptake, transsulfuration pathway activity, or increased GPX4-mediated GSH utilization, revealing a non-canonical ferroptosis mechanism driven by enhanced GSH catabolism