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In the TME, redox imbalance driven by features such as hypoxia, metabolic reprogramming, and chronic inflammation is a key factor leading to genetic instability and malignant tumor progression [178]

Furthermore, stabilization of NRF2 in cancer cells harboring oncogenic RAS induces genes encoding stress-responsive enzymes, including GPXs, NAD(P)H:quinone oxidoreductase-1 (NQO1), glutamate-cysteine ligase (GCL), GR, heme oxygenase-1 (HO-1), and glutathione S-transferase (GST), some of which are directly involved in cellular glutathione biosynthesis and ROS detoxification 22,23,24

Dig Dis Sci 56(7):20882097 Schwaiger T (2018) The uses of low-dose naltrexone in clinical practice

Additionally, this review incorporates research on nanoparticle-based delivery systems, which play a critical role in optimizing the therapeutic efficacy of UA and ensuring targeted drug delivery to tumor sites