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You should not take bupropion if: You are allergic to bupropion or any ingredient in the medication You currently have, or have a history of, seizures or other conditions that make you more likely to have a seizure, such as an eating disorder like anorexia or bulimia, severe head injury, stroke, brain tumor, or other central nervous system (CNS) conditions You abruptly stop alcohol, antianxiety drugs, barbiturates, or anticonvulsants You have taken an MAOI in the past 14 days You currently use alcohol Certain other health conditions require a healthcare professional to weigh the benefits and risks of prescribing bupropion, and if prescribed bupropion, the patient will be closely monitored