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Since warfarin initially decreases protein C levels faster than the coagulation factors, it can paradoxically increase the blood's tendency to coagulate when treatment is first begun (many patients when starting on warfarin are given heparin in parallel to combat this), leading to massive thrombosis with skin necrosis and gangrene of limbs

78 These DAMPs play a major role in promoting neutrophil infiltration by activating antigen-presenting cells, including Kupffer cells and dendritic cells, which amplifies the immune response and the progression of liver injury

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