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The adaptogenic herbs Rhodiola rosea, Ashwagandha, and Eleuthero as well as the herbs Licorice root, Astragalus, Gotu Kola, and Schizandra all provide a synergistic effect by supporting normal, healthy adrenal function, supporting healthy cortisol and energy levels, managing the negative effects of stress on the body and contributing to an overall feeling of well-being

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Among these, cardiotoxicity stands out as the most clinically limiting adverse effect, often determining the upper threshold of cumulative dosing