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Groop PH, Cooper ME, Perkovic V, Emser A, Woerle HJ, Von Eynatten M

A ligature was placed around the cervix of the lower left first molar as described in Materials and Methods in 36 rats to induce unilateral periodontitis

Loading phase protocol (acute injury or initial treatment): Dose: 500 mcg to 1 mg per injection Frequency: Once daily Duration: 7 to 10 days Injection site: Subcutaneous, ideally near the area of concern Timing: Morning or evening, consistency matters more than specific time Maintenance phase protocol: Dose: 500 mcg to 1 mg per injection Frequency: 2 to 3 times per week Duration: 4 to 8 weeks total protocol length Cycle recommendation: 2 months on, 2 months off Unlike traditional BPC-157 acetate, which is often administered twice daily due to its shorter half-life, the enhanced stability of the arginate form typically allows for once-daily dosing during the loading phase

10.1007/s11916-019-0799-4 Curr