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An alternative regulation of Nrf2 involves the p62 autophagy-related protein (sequestosome 1-SQSTM1) in a Keap1-dependent manner

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There are several underlying mechanisms that have been implicated in this age-related muscle wasting: decreased protein synthesis, reduced enzymatic activity (especially in glycolytic and glycogenolytic pathways), depletion in energy reserves, increased oxidative damage, and changes in ion content[351], among others