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doi: 10.2967/jnumed.113.133389

The child's guardian was given the CRWP or the placebo as randomized in powder form in canisters at two different visits, at week 0 (baseline) and week 6, and asked to bring the used canisters back to study personnel after weeks 6 and 12 (follow-up) for it to be weighed

The authors suggest that 17-estradiol may still upregulate PKC isozymes differently, that is increasing some while decreasing others resulting in little overall change to PKC activity [54], however future studies are needed to confirm this assertion [54]