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Abbreviations ABCs: Age-associated B cells AID: Activation-induced cytidine deaminase ART: Antiretroviral therapy CAR-T: Chimeric antigen receptor T-cell cGPDH: Glycerol-3-phosphate dehydrogenase CMV: Cytomegalovirus CpG: Cytosine-phosphate-Guanine D + Q: Quercetin and dasatinib DCs: Dendritic cells DN: Double-negative DP: Double-positive E47: Transcription factor E47 FFAR4: Free fatty acid receptor 4 GCA: Grancalcin GLUT1: Glucose transporter 1 GSH: Glutathione GVHD: Graft-versus-host disease HSCs: Haematopoietic stem cells HSPCs: Haematopoietic stem/progenitor cells INSTIs: Integrase strand transfer inhibitors iPSCs: Inducing pluripotent stem cells KIR: Killer-cell immunoglobulin-like receptors KLRG1: G1-Killer cell lectin-like receptor subfamily G member 1 LYVE1: Lymphatic Vessel Endothelial Hyaluronan Receptor 1 mDCs: Myeloid dendritic cells METTL3: Methyltransferase-like 3 mtDNA: Mitochondrial DNA mTOR: Mechanistic target of rapamycin NAD: Nicotinamide adenine dinucleotide NK: Natural killer cell NMN: Nicotinamide mononucleotide NNRTIs: Non-nucleoside Reverse Transcriptase Inhibitors NR: Nicotinamide riboside NRTIs: Nucleoside Reverse Transcriptase Inhibitors P2X7: P2X purinoceptor 7 PAMPs: Pathogen-associated molecular patterns pDCs: Plasmacytoid dendritic cells PHS: Phytosphingosine PIs: Protease Inhibitors PRRs: Pattern recognition receptors PWH: People with HIV ROS: Reactive oxygen species RTEs: Recently emigrated thymocytes RUNX3: Runt-related transcription factor 3 SASP: Senescence-associated secretory phenotype SA--Gal: Senescence-associated beta-galactosidase SHMT2: Serine hydroxymethyltransferase 2 SIV: Simian immunodeficiency virus TCR: T-cell receptor TEMRA: Terminally Differentiated Effector Memory T Cells ThPOK: T helper-inducing POZ/Krueppel-like factor TLR: Toll-like receptors TRE: Time-restricted eating TRIB2: Tribbles pseudokinase 2 T1: Thymosin alpha 1 uPAR: Urokinase-type plasminogen activator receptor VOCs: Volatile organic compounds Vpr: HIV-1 viral protein R ZEB2: Zinc finger E-box-binding homeobox 2 -KG: Alpha-ketoglutarate m: Mitochondrial membrane potential References UNAIDS

Life Sci 2024;339:122411

9 Sanchez-Garrido MA, Tena-Sempere M

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