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Several key factorsincluding the pharmacologic targets of the drugs, host metabolism, genetic variability, and drug-drug interactionscontribute to the overall toxicity profile of oral agents

Generation of the first structure-based pharmacophore model containing a selective zinc binding group feature to identify potential glyoxalase-1 inhibitors

For instance, oxidative stress may lead to, and be caused by, mitochondrial dysfunction which leads to the release of mitochondrial DNA and other mitochondrial components into the cytosol, triggering cell senescence, thereby enhancing inflammation via activation of the SASP, which, in turn, may promote localized tissue fibrosis

These findings identify ALC as a metabolic regulator that restores social isolation-induced myelin deficits by coordinating myelin protein synthesis, mitochondrial function, and myelin lipid remodeling