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This opens avenues for developing small-molecule PGC-1 agonists or strategies to modulate DDIT4 as pharmacologic alternatives to cell therapy, which could circumvent the logistical and regulatory complexities associated with live cell administration

[] Increased activity of microglial cells (inflammatory processes, phagocytosis, disruption of the bloodbrain barrier and increased synthesis of oestrogen) was linked to increased ROS and unstable behaviours in mice

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MAPKi-resistant BRAF-mutated melanoma also shows increased FAO and peroxisome biogenesis