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Hepatic knockdown of GADD45 exacerbates steatohepatitis in MCD mice To investigate the role of hepatic GADD45 in steatohepatitis, C57BL/6J mice fed an MCD diet were injected with adenoviral shRNA targeting GADD45 via the tail vein, which effectively reduced hepatic GADD45 expression (Fig

It represents a fundamentally different pharmacological strategy, one that early clinical data suggests could nearly double the weight loss seen with semaglutide while simultaneously delivering dramatic improvements in liver fat, metabolic markers, and body composition

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