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A critical methodological gap exists here: the overwhelming majority of laboratory-based fate and ecotoxicology studies use pristine ENMs dispersed in simplified media as their model system

Collectively, these studies establish the pyrrolo [2,3- d ] pyrimidine analog AGF347 as an exciting prototype for multi-targeting mitochondrial and cytosolic C1 metabolism for cancer, with substantial promise for overcoming resistance to current anticancer therapies [12]