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Therefore, we conclude that both high temperature regimes affect profoundly the reduced glutathione level rather than the oxidized glutathione and that wild-type plants are adapting their glutathione metabolism in response to high temperatures (Figure 2)

Cyclosporin A has been used as a rescue therapy in adults with AIH, with limited data available in the literature, including small retrospective series, small prospective uncontrolled and open studies and case reports [197, 198]