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MOTS-c may be particularly valuable for women experiencing perimenopause or menopause-related belly fat accumulation due to its effects on AMPK and estrogen-related metabolic pathways

Regular blood monitoring of liver function, kidney function, and full blood count remains essential for methotrexate users

Initiate supplementation with oral folic acid and intramuscular vitamin B12 to reduce the severity of hematologic and gastrointestinal toxicity of ALIMTA