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Patients with CS pruritus had significantly higher (worse) scores on all PBC-40 domains than those with non-CS pruritus, and patients with any pruritus scored significantly worse than those with no pruritus

It is a precursor to and supports tissue levels of glutathione (GSH), the principle defense within the body against reactive oxygen species (ROS) and the detoxification of drugs, metabolites and other compounds

Its prevalence is influenced by demographic factors and is linked to painful conditions such as gout and kidney stones

Early feasibility studies highlighted both the promise and the challenges of implementing strict dietary regimens