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However, a potential role of other ALOX isoforms (ALOX15B, ALOX12, ALOX12B, ALOXE3) in AD has not been explored

On the one hand, p53 has been reported to increase ROS levels via its target genes such as PUMA, quinone oxidoreductase and a proline oxidoreductase, and the pro-oxidant function has been shown to contribute to p53-induced cell death [299,300,301,302]