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Although sleep deprivation is not a medical condition, it is linked to higher risk of a number of diseases, including high blood pressure, cardiovascular disease, diabetes, daytime drowsiness, and mental health problems

REW-IgG subclasses show favorable FcRn engagement but distinct effector functions As the REW substitutions are conserved among the four human IgG subclasses, we made REW engineered anti-NIP versions, in addition to a recombinant form of the IgG1 Fc fusion molecule etanercept (Fig

Notably, all the docked poses demonstrated substantial intermolecular contacts formation with essential residues (His 61 , His 85 , His 94 , His 259 , and His 263 ) and binuclear copper active site in the mh-Tyr enzyme (Table S1, Fig