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Of note, through histopathological and immunofluorescence analyses of immune cell subsets, we confirmed that lowering oxalate via AGXT overexpression or pharmacological inhibition of LDHA and GO reduces steatohepatitis aligned with the decrease in distinct subsets of recruited monocyte-derived macrophages (CCR2 + and TREM2 + macrophages) that are known to infiltrate the liver in MASH and form crown-like structures surrounding hepatocytes with large lipid droplets 49

doi: 10.1164/ajrccm.159.6.9804054 79 van der CrabbenS

Novel therapies for coeliac disease

and (viii) an isolated complementarity determining region (CDR) or (ix) a combination of two or more isolated CDRs which may optionally be joined by a synthetic linker