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A secondary viremia begins on about the eighth day and is followed by fever and toxemia

The oncometabolite fumarate promotes pseudohypoxia through noncanonical activation of NF-kappaB signaling

Kadara H, Choi M, Zhang J, Parra ER, Rodriguez-Canales J, Gaffney SG, Zhao Z, Behrens C, Fujimoto J, Chow C, Yoo Y, Kalhor N, Moran C, Rimm D, Swisher S , Gibbons DL, Heymach J, Kaftan E, Townsend JP, Lynch TJ, Schlessinger J, Lee J, Lifton RP, Wistuba II, Herbst RS

Two thousand and sixty-five hepatitis B antigen-positive men from Qidong were randomised into two groups: 1112 received 05 mg Se/d (as sodium selenite) and 953 men received a placebo (Reference Li, Zhu and Yan31)