glutathione peroxidase selenium cofactor PRDX6 dictates ferroptosis sensitivity by directing cellular utilization: Molecular Cell playing a crucial role in protecting against oxidative stress and free radicals GPX1 (Glutathione Peroxidase, GSHPx) Gene

[DOI] [PubMed] [Google Scholar] 18.Manyes L., Luciano F.B., Manes J., Meca G

The discrepancy between this study and the data herein may reflect the heterogeneous nature of CD and disease severity between the patient donors (the current study used monocytes from individuals with mild-to-moderate CD), the mechanisms of action of the various pro-death stimuli, or differences in apoptotic versus non-apoptotic death in macrophages

Correlating longitudinal multi-omics data from large, well-annotated patient cohorts with clinical outcomes will thus enable accurate patient stratification, guide therapeutic decision-making, and increase the success rate of clinical trials

Lipoxygenases generate highly reactive peroxidation products of unsaturated fatty acids prone to further lipid peroxidation and GPX4 reduces lipid peroxidation products in membranes to stable hydroxyl-derivatives ( Gpx4 -knockout mice are phenotypically characterized by ineffective erythropoiesis ( The Role of GSH Depletion and GPX4 in Ferroptosis Ferroptosis has recently emerged as a new cell death modality