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For established cognitive support, the evidence-based options include aerobic exercise (strong evidence for cognitive benefits, especially executive function and processing speed), sleep optimization (critical for cognitive function), Mediterranean diet (modest evidence for cognitive protection over years), treating sleep apnea (significant cognitive improvements when this condition is addressed), treating depression (major cognitive effects when present), donepezil and other approved Alzheimer drugs (modest evidence-based effects in actual Alzheimer disease), and stimulants (well-established for ADHD)

A vial stored at 15C with zero fluctuation will outperform one stored at 25C that experiences daily freeze-thaw cycles from a self-defrosting freezer

13,14 Therefore, gabapentin monotherapy should not be used in severe AWS or in those with a history of AWS seizures or who are at risk for progression to severe AWS