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Manipulating kynurenic acid levels in the brain - on the edge between neuroprotection and cognitive dysfunction

The included studies were selected if they had used streptozotocin (STZ) as the drug which was injected to the mice and rats to develop diabetic cardiomyopathy in addition to a high-fat diet

Methyl Donors: Betaine and Choline Betaine is the methyl donor in the BHMT pathway and is a methylamine as it contains three chemically reactive methyl groups linked to a nitrogen atom