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Due to its simple administration and the low risk of complications, autologous bone marrow applied locally and, in particular, intramuscularly administered osteogenous substances such as TRIS-BPC157, are advantageous over other more complex surgical methods (i.e., bone grafts, vascularized bone grafts, method of Ilizarov) for the treatment of healing impairments in humans

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made use of the RPTEC/TERT1 cell line to evaluate transepithelial transports in a small set of known nephrotoxic and non-nephrotoxic drugs, demonstrating that further evaluation of functional parameters, including transepithelial electrical resistance (TEER), reabsorption, and secretion of solutes, is essential to understand the nephrotoxicity mechanisms of drugs and predict the in vivo implication in regards to kidney performance (Secker et al