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A U-shaped trajectory was observed, with initial improvement followed by worsening of depression, anxiety, fatigue, sleep disturbance, and stigma

FIGURE 9 4 Discussion GHK and its bioactive form, GHK-Cu, have been demonstrated to be safe and effective in various cellular, tissue, and animal models ( In IBD, the expression levels of tight junction proteins such as ZO-1 and Occludin, is generally suppressed, leading to increased intestinal permeability, enhanced pathogen infiltration, and exacerbated inflammatory responses ( in vivo and in vitro experimental models revealed that GHK-Cu upregulates the expression level of Occludin and ZO-1, suggesting its potential role in promoting intestinal barrier repair

Nature Medicine 22(1):78-83

For subcutaneous and intramuscular injection, acetate BPC-157 delivers the full peptide directly into tissues where it can act immediately