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Preclinical models used oral dosing at 50100mg/kg body weight, but human-equivalent subcutaneous protocols typically range from 30mg to 50mg per injection, administered once daily

These B12 drug interactions are especially important to consider for individuals taking multiple medications

Homozygous and mutated SLC19A3 gene can cause various conditions such as biotin-thiamine responsive basal ganglia disease (BTBGD), lactic acidosis combined with encephalopathy, infantile epileptic spasms, and early childhood encephalopathy induced by disease or trauma

While this efficiency is generally beneficial, in environments of excess caloric intake it may contribute to fat accumulation