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Ghrelin also acts through a GPCR but in this case the activation of this receptor leads to the stimulation of the activity of phospholipase C (PLC) that induces the formation of inositol 1,4,5-triphosphate (IP3), and diacylglycerol (DAG) ( Figure 5 )

Furthermore, partial epigenetic reprogramming falls under the umbrella of experimental therapeutics known as cellular rejuvenation, which several well-funded biotech startups, backed by high-profile executives, have focused on in recent years

Moreover, alteration of the administration order of Bu-Cy to Cy-Bu gives the same engraftment outcome but reduces the toxicity of the conditioning regimen both in patients and mice 59,60