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Introduction Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has been reported, as of September 2022, in more than 600 million confirmed cases and has led to more than 6.4 million deaths worldwide ( While most COVID-19 patients will experience mild symptoms, some will develop severe acute respiratory distress syndrome, systemic inflammation, multiple organ failure, and other more serious complications that can lead to death

Managing Expectations & Practical Guidance for Patients As orforglipron moves toward approval and commercial availability, patients, providers, and the broader public will need realistic expectations about what this drug can and cannot do