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Edmonds R, Steffen V, Honigberg LA, Chang MC

It converts to NADH and powers ATP production through oxidative phosphorylation DNA repair - NAD+ helps PARP enzymes detect and fix damaged DNA, which keeps the genome stable Sirtuin activation - Sirtuins need NAD+ as a cofactor to regulate metabolism, cellular senescence, and DNA repair NAD+ also helps remodel chromatin, sends cellular signals, and regulates circadian rhythms by working with various enzymes

Importantly, HIF-1 contributes to an acidic TME and induces lipid droplet accumulation that can be used for energy production [203]

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