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Key mediators such as interleukin-6 (IL-6), IL-1, IL-8, and tumor necrosis factor- (TNF-) play pivotal roles in triggering the innate immune response, thereby promoting follicular hyperkeratosis and the characteristic inflammatory lesions of acne

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separation occurs in the terminal ileum in the presence of calcium, and vitamin B 12 enters the mucosal cell for absorption

On the other hand, excessive exposure to manganese has been linked to neurobehavioral disorder in both adults and children [5]