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That's because typically they have less of the enzyme in their stomach that helps to metabolize alcohol

Edinger JD, Wohlgemuth WK, Krystal AD, Rice JR

Thus, it has been pointed out that the brain is totally reliant on methionine synthase activity to remethylate homocysteine (19)

Future studies leveraging the genetic tractability of Drosophila could further dissect the molecular pathways influenced by such natural compounds, accelerating the discovery of novel AD therapeutics