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or secondary as a consequence of environmental factors and/or medications (shift work, spinal cord cervical transection, sympathectomy, aging, neurodegenerative diseases, genetic diseases, -blockers, calcium channel blockers, ACE inhibitors)

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Furthermore, SCD expression correlates negatively with immunosuppressive molecules, such as lymphocyte activation gene 3 protein (LAG3), galectin-9 (GAL9), programmed cell death 1 ligand 1 (PD-L1) and cytotoxic T-lymphocyte protein 4 (CTLA4), whereas it shows positive correlations with immune activation molecules such as tumor necrosis factor receptor superfamily member 18 (TNFRSF18), tumor necrosis factor ligand superfamily member 4 (TNFSF4) and CD47