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After their translation, Per and Cry translocate to the nucleus and create a negative feedback loop, inhibiting both CLOCK and BMAL1 [181, 182]

Two strategies dominate: structural stabilization (modifications that resist proteases) on one side, and small non-peptide agonists that mimic a peptide's action without its fragility on the other

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240 One mechanism by which PQQ may benefit those with Parkinsons disease is by stimulating cerebral blood flow and oxygen use