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The fluid of most sequestered sites in the body (cerebrospinal fluid, accessory sex gland fluid, milk, abscesses) has a pH more acidic than plasma

In vitro and animal studies have found that lipoic acid exhibits immunomodulatory properties through mechanisms that stimulate the production of cyclic AMP (cAMP) (90, 91) a central regulator of innate immune functions and inhibits the migration of immune cells into the brain and spinal cord (92), possibly by decreasing endothelial expression of cell adhesion molecules, inhibiting expression of enzymes like matrix metalloproteinases (MMP), and/or reducing the permeability of the blood-brain barrier (87, 89, 93, 94)

Shull, J

Despite the existence of several therapeutic modalities, namely psychotherapy and antidepressants, there are several problems associated with the therapy of this disease, such as the development of resistance and relapses after the end of therapy