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doi:10.1001/jama.2009.1622 [10] Arakawa Y, Watanabe M, Inoue N, et al

Inflammatory molecules produced by meniscus and synovium in early and end-stage osteoarthritis: a coculture study

Mice with inactivating mutations in the gene coding for the enzyme alcohol dehydrogenase 5 (Adh5) and in the gene coding for the factor Fanconi Anaemia Complementation Group D2 (Fancd2) accumulate FA-DNA adducts and present hematopoietic stem cell attrition, which correlates with genome instability in the hematopoietic compartment 9