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C., & de Wit, J

Oxidative stress in Alzheimers disease: why did antioxidant therapy fail

For example, NaAsO2 treatment of human bronchial epithelial (HBE) cells inhibits TET-mediated DNA demethylation and induces promoter hypermethylation of 8-oxoguanine DNA glycosylase (OGG1) and glutathione stransferase Pi 1(GSTP1) [139]

Upon binding to AREs in the nucleus, NRF2 interacts with other co-activators, such as the CBP/p300 protein, forming a complex that further activates the transcription of antioxidant and detoxification genes [30]