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injection Digoxin elimination follows first-order kinetics Following intravenous administration to healthy volunteers, 50% to 70% of a digoxin dose is excreted unchanged in the urine Renal excretion of digoxin is proportional to glomerular filtration rate and is largely independent of urine flow In healthy volunteers with normal renal function, digoxin has a half-life of 1.5 to 2.0 days Side Effects: Note: Digoxin's TI is relatively low (~2) Adverse effects are dose-dependent and typically occur at doses higher than those needed to achieve a therapeutic effect