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LOOH, lipid peroxides

Anatomically, the most anterior portion of the cornea is a stratified epithelial cell layer with a strong barrier function, followed by the stroma composed of tightly packed collagen fibers, and finally, by organized single columnar endothelium

Marabini L, Cal R, Braga PC

These findings of increased transcription of cellular adhesion molecules and inhibition of eNOS production of nitric oxide are hallmarks of vascular endothelial dysfunction 47 , providing potential mechanistic insight on the connection between gut microbial reorganization, subsequent PAGln production, and their role in the manifestation of vascular dysfunction