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Science 350 (6264), 10891092

The neurotransmitters glutamate and glycine decrease magnesium's affinity for the binding site, allowing controlled entry of calcium into the cell.37,38 When magnesium is depleted, the gate opens and calcium floods in

Sci Rep 2018;8(1):17131

What Makes Periorbital Skin So Vulnerable A 2019 clinical assessment published in Clinical, Cosmetic and Investigational Dermatology confirmed that under-eye dark circles correlate with measurably thinner skin, higher hemoglobin index (a marker of vascular prominence), and a higher melanin index all pointing to both vascular and pigmentary contributors rather than just one single cause