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Patients with CHB had significantly higher medical and drug costs than the control, especially when they developed decompensation, HCC, or liver transplantation

In addition to these effects, the ketogenic diet may be promoting mitophagy through upregulation of HIF-1 despite normoxic conditions, as exhibited in investigations of rat brains on this diet, therefore leading to transcription of BNIP3 and BNIP3L (NIX) (Puchowicz et al., 2008

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