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In HCCs that arise in mice maintained on high-fat diets, USP30 was phosphorylated and stabilized by IKK, and USP30 deletion attenuated lipogenesis and tumorigenesis in DEN/CCl4-induced animal model [48]

Levodopa substitution is still the most effective approach to treat PD motor symptoms, but standard oral drug delivery is associated with plasma level oscillations that give rise to the development of motor fluctuations and dyskinesias